T\u0131p uzun y\u0131llar boyunca hastal\u0131kla sava\u015ft\u0131.
\nBir \u015fey fazlaysa azaltt\u0131. Eksikse yerine koydu. A\u015f\u0131r\u0131 \u00e7al\u0131\u015fan bir sistemi bask\u0131lad\u0131.<\/p>\n
Bu k\u00f6t\u00fc bir yakla\u015f\u0131m de\u011fildi. Aksine modern t\u0131bb\u0131n ba\u015far\u0131s\u0131 buradan geldi. Antibiyotikler, tansiyon ila\u00e7lar\u0131, ins\u00fclin\u2026 Hepsi sorunu hedef al\u0131p m\u00fcdahale etme mant\u0131\u011f\u0131yla \u00e7al\u0131\u015ft\u0131.<\/p>\n
Ama baz\u0131 hastal\u0131klar var ki, bu y\u00f6ntemle tam d\u00fczelmiyor.<\/p>\n
Alzheimer bunlardan biri.<\/p>\n
Y\u0131llard\u0131r amiloid plaklar\u0131 hedefliyoruz. Beyinde biriken proteini azaltmaya \u00e7al\u0131\u015f\u0131yoruz. Mant\u0131k basit. Birikim varsa temizleyelim. Fakat plak azal\u0131nca her zaman haf\u0131za d\u00fczelmiyor. \u0130\u015fte burada insan durup d\u00fc\u015f\u00fcn\u00fcyor;<\/p>\n
Sorun ger\u00e7ekten sadece o protein mi?<\/p>\n
Massachusetts Institute of Technology\u2019de yap\u0131lan baz\u0131 deneylerde 40 Hz denilen belirli bir beyin ritmini art\u0131ran \u0131\u015f\u0131k ve ses uyar\u0131lar\u0131n\u0131n Alzheimer farelerinde amiloid y\u00fck\u00fcn\u00fc azaltt\u0131\u011f\u0131 g\u00f6sterildi. \u0130nsanlarda yap\u0131lan erken \u00e7al\u0131\u015fmalarda ise bu uygulaman\u0131n g\u00fcvenli oldu\u011fu ve ger\u00e7ekten o ritmi art\u0131rabildi\u011fi g\u00f6r\u00fcld\u00fc.<\/p>\n
Bu hen\u00fcz bir tedavi de\u011fil. Ama bir soru i\u015fareti ve ba\u015flang\u0131\u00e7.<\/p>\n
Belki mesele yaln\u0131zca proteini temizlemek de\u011fil.
\nBelki mesele, bozulan uyumu yeniden kurmak.<\/p>\n
\u00c7\u00fcnk\u00fc beyin sadece kimyasal bir organ de\u011fil. Ayn\u0131 zamanda elektrikle \u00e7al\u0131\u015fan bir a\u011f. N\u00f6ronlar ritim i\u00e7inde ate\u015flenir. Haf\u0131za ve dikkat bu senkron sayesinde olu\u015fur. E\u011fer o ritim bozulursa, sistem da\u011f\u0131l\u0131r.<\/p>\n
Belki Alzheimer yaln\u0131zca \u201cplak hastal\u0131\u011f\u0131\u201d<\/strong> de\u011fildir. Belki bir senkron kayb\u0131d\u0131r.<\/p>\n Transcranial Magnetic Stimulation depresyonda kullan\u0131l\u0131yor. Ortak fikir \u015fu; Kalp ritimle \u00e7al\u0131\u015f\u0131r. Ritmi bozulursa aritmi olur. Belki sorun fazla olan bir madde de\u011fil, kaybolmu\u015f bir uyumdur. T\u0131p hala temkinli. Olmak zorunda. Hastal\u0131kla sava\u015fmak m\u0131? Belki cevap, ikisini birlikte yapabilmektir.<\/p>","protected":false},"excerpt":{"rendered":" T\u0131p hala temkinli. Olmak zorunda. Ama y\u00f6n de\u011fi\u015fimi bazen en b\u00fcy\u00fck ilerlemedir.<\/p>","protected":false},"author":23,"featured_media":282823,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[286],"tags":[289],"class_list":{"0":"post-282822","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-yazarlar","8":"tag-manset"},"_links":{"self":[{"href":"https:\/\/halkweb.com.tr\/en\/wp-json\/wp\/v2\/posts\/282822","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/halkweb.com.tr\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/halkweb.com.tr\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/halkweb.com.tr\/en\/wp-json\/wp\/v2\/users\/23"}],"replies":[{"embeddable":true,"href":"https:\/\/halkweb.com.tr\/en\/wp-json\/wp\/v2\/comments?post=282822"}],"version-history":[{"count":1,"href":"https:\/\/halkweb.com.tr\/en\/wp-json\/wp\/v2\/posts\/282822\/revisions"}],"predecessor-version":[{"id":282824,"href":"https:\/\/halkweb.com.tr\/en\/wp-json\/wp\/v2\/posts\/282822\/revisions\/282824"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/halkweb.com.tr\/en\/wp-json\/wp\/v2\/media\/282823"}],"wp:attachment":[{"href":"https:\/\/halkweb.com.tr\/en\/wp-json\/wp\/v2\/media?parent=282822"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/halkweb.com.tr\/en\/wp-json\/wp\/v2\/categories?post=282822"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/halkweb.com.tr\/en\/wp-json\/wp\/v2\/tags?post=282822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nFocused ultrasound ile beynin derin b\u00f6lgeleri ameliyats\u0131z hedeflenebiliyor.<\/p>\n
\nBaz\u0131 hastal\u0131klarda art\u0131k sistemi susturmak de\u011fil, sistemi yeniden ayarlamak hedefleniyor.<\/p>\n
\nMetabolizma g\u00fcn \u0131\u015f\u0131\u011f\u0131na g\u00f6re ayarlan\u0131r. Saat bozulursa her \u015fey da\u011f\u0131l\u0131r.
\nBeyin de ritimle \u00e7al\u0131\u015f\u0131r. O ritim kaybolursa haf\u0131za da kaybolabilir.
\n20. y\u00fczy\u0131l molek\u00fclleri hedef ald\u0131.
\n21. y\u00fczy\u0131l belki a\u011flar\u0131 hedef alacak.<\/p>\n
\nBelki baz\u0131 hastal\u0131klarda ger\u00e7ek devrim yeni bir ila\u00e7 de\u011fil, bozulan sistemi yeniden kurabilmektir.<\/p>\n
\nAma y\u00f6n de\u011fi\u015fimi bazen en b\u00fcy\u00fck ilerlemedir.<\/p>\n
\nYoksa sistemi yeniden kurmak m\u0131?<\/p>\n